655.1K XNAS Volume
XNAS 20 Mar, 2025 5:30 PM (EDT)
| Client Name | Client Category | Action | Reported to Exchange | Quantity | Post Transaction Holding | Traded % | Avg. Price | Value | Security Type |
|---|---|---|---|---|---|---|---|---|---|
| Robert J. Marshall | CFO and Treasurer | Sale of securities on an exchange or to another person at price $ 100.52 per share. | 17 Mar 2025 | 10,000 | 113,860 (0%) | 0% | 100.5 | 1,005,200 | Common Stock |
| Brian A. Markison | Director, CEO | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 05 Mar 2025 | 70,909 | 232,420 (0%) | 0% | 0 | Common Stock | |
| Brian A. Markison | Director, CEO | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 05 Mar 2025 | 41,347 | 41,347 | - | - | Stock Option (right to buy) | |
| Robert J. Marshall | CFO and Treasurer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 05 Mar 2025 | 23,884 | 123,860 (0%) | 0% | 0 | Common Stock | |
| Robert J. Marshall | CFO and Treasurer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 05 Mar 2025 | 13,927 | 13,927 | - | - | Stock Option (right to buy) | |
| Paul M. Blanchfield | President | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 05 Mar 2025 | 15,668 | 15,668 | - | - | Stock Option (right to buy) | |
| Paul M. Blanchfield | President | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 05 Mar 2025 | 26,871 | 118,699 (0%) | 0% | 0 | Common Stock | |
| Paul M. Blanchfield | President | Sale of securities on an exchange or to another person at price $ 98.00 per share. | 05 Mar 2025 | 2,084 | 91,828 (0%) | 0% | 98 | 204,232 | Common Stock |
| Daniel M. Niedzwiecki | See Remarks | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 05 Mar 2025 | 23,884 | 99,235 (0%) | 0% | 0 | Common Stock | |
| Daniel M. Niedzwiecki | See Remarks | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 05 Mar 2025 | 13,927 | 13,927 | - | - | Stock Option (right to buy) | |
| Amanda Morgan | Chief Commercial Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 05 Mar 2025 | 14,928 | 39,580 (0%) | 0% | 0 | Common Stock | |
| Amanda Morgan | Chief Commercial Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 05 Mar 2025 | 8,704 | 8,704 | - | - | Stock Option (right to buy) | |
| Brian A. Markison | Director, CEO | Payment of exercise price or tax liability using portion of securities received from the company at price $ 94.86 per share. | 03 Mar 2025 | 8,637 | 161,511 (0%) | 0% | 94.9 | 819,306 | Common Stock |
| Mary Anne Heino | Director | Sale of securities on an exchange or to another person at price $ 93.32 per share. | 03 Mar 2025 | 9,160 | 478,081 (1%) | 0% | 93.3 | 854,811 | Common Stock |
| Mary Anne Heino | Director | Sale of securities on an exchange or to another person at price $ 94.09 per share. | 03 Mar 2025 | 15,017 | 463,064 (1%) | 0% | 94.1 | 1,412,950 | Common Stock |
| Mary Anne Heino | Director | Sale of securities on an exchange or to another person at price $ 95.40 per share. | 03 Mar 2025 | 17,694 | 445,370 (1%) | 0% | 95.4 | 1,688,008 | Common Stock |
| Mary Anne Heino | Director | Sale of securities on an exchange or to another person at price $ 95.91 per share. | 03 Mar 2025 | 4,971 | 440,399 (1%) | 0% | 95.9 | 476,769 | Common Stock |
| Mary Anne Heino | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 03 Mar 2025 | 50,070 | 493,506 (1%) | 0% | 0 | Common Stock | |
| Mary Anne Heino | Director | Sale of securities on an exchange or to another person at price $ 92.29 per share. | 03 Mar 2025 | 6,265 | 487,241 (1%) | 0% | 92.3 | 578,197 | Common Stock |
| Robert J. Marshall | CFO and Treasurer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 03 Mar 2025 | 17,274 | 120,237 (0%) | 0% | 0 | Common Stock | |
| Robert J. Marshall | CFO and Treasurer | Payment of exercise price or tax liability using portion of securities received from the company at price $ 94.86 per share. | 03 Mar 2025 | 20,261 | 99,976 (0%) | 0% | 94.9 | 1,921,958 | Common Stock |
| Paul M. Blanchfield | President | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 03 Mar 2025 | 13,769 | 110,506 (0%) | 0% | 0 | Common Stock | |
| Paul M. Blanchfield | President | Payment of exercise price or tax liability using portion of securities received from the company at price $ 94.86 per share. | 03 Mar 2025 | 16,594 | 93,912 (0%) | 0% | 94.9 | 1,574,107 | Common Stock |
| Daniel M. Niedzwiecki | See Remarks | Payment of exercise price or tax liability using portion of securities received from the company at price $ 94.86 per share. | 03 Mar 2025 | 12,907 | 75,351 (0%) | 0% | 94.9 | 1,224,358 | Common Stock |
| Daniel M. Niedzwiecki | See Remarks | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 03 Mar 2025 | 10,514 | 88,258 (0%) | 0% | 0 | Common Stock | |
| Amanda Morgan | Chief Commercial Officer | Payment of exercise price or tax liability using portion of securities received from the company at price $ 94.86 per share. | 03 Mar 2025 | 759 | 24,652 (0%) | 0% | 94.9 | 71,999 | Common Stock |
| Phuong Khanh Morrow | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 07 Feb 2025 | 563 | 563 (0%) | 0% | 0 | Common Stock | |
| Phuong Khanh Morrow | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 07 Feb 2025 | 1,017 | 1,017 | - | - | Stock Option (right to buy) | |
| Phuong Khanh Morrow | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 07 Feb 2025 | 1,015 | 1,015 | - | - | Stock Option (right to buy) | |
| James H. Thrall | Director | Sale of securities on an exchange or to another person at price $ 94.76 per share. | 15 Jan 2025 | 1,000 | 33,207 (0%) | 0% | 94.8 | 94,760 | Common Stock |
| Markison Brian A. | Director, CEO | Exercise or conversion of derivative security received from the company (such as an option) at price $ 6.00 per share. | 19 Dec 2024 | 16,666 | 185,594 (0%) | 0% | 6 | 99,996 | Common Stock |
| Markison Brian A. | Director, CEO | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 19 Dec 2024 | 16,102 | 0 | - | - | Stock Option (right to buy) | |
| A. Markison Brian | Director, CEO | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 19 Dec 2024 | 16,666 | 0 | - | - | Stock Option (right to buy) | |
| A. Markison Brian | Director, CEO | Exercise or conversion of derivative security received from the company (such as an option) at price $ 12.42 per share. | 19 Dec 2024 | 16,102 | 168,928 (0%) | 0% | 12.4 | 199,987 | Common Stock |
| A. Markison Brian | Director, CEO | Payment of exercise price or tax liability using portion of securities received from the company at price $ 91.15 per share. | 19 Dec 2024 | 15,446 | 170,148 (0%) | 0% | 91.2 | 1,407,903 | Common Stock |
| Robert J. Marshall | CFO and Treasurer | Sale of securities on an exchange or to another person at price $ 81.20 per share. | 15 Nov 2024 | 10,000 | 102,963 (0%) | 0% | 81.2 | 812,000 | Common Stock |
| Paul M. Blanchfield | President | Sale of securities on an exchange or to another person at price $ 79.65 per share. | 14 Nov 2024 | 2,000 | 97,092 (0%) | 0% | 79.7 | 159,300 | Common Stock |
| Paul M. Blanchfield | President | Gift of securities by or to the insider at price $ 0.00 per share. | 14 Nov 2024 | 355 | 96,737 (0%) | 0% | 0 | Common Stock | |
| Mary Anne Heino | Director | Sale of securities on an exchange or to another person at price $ 86.32 per share. | 08 Nov 2024 | 7,487 | 447,436 (1%) | 0% | 86.3 | 646,278 | Common Stock |
| Mary Anne Heino | Director | Sale of securities on an exchange or to another person at price $ 89.58 per share. | 08 Nov 2024 | 700 | 443,436 (1%) | 0% | 89.6 | 62,706 | Common Stock |
| Mary Anne Heino | Director | Sale of securities on an exchange or to another person at price $ 88.78 per share. | 08 Nov 2024 | 2,900 | 444,136 (1%) | 0% | 88.8 | 257,462 | Common Stock |
| Mary Anne Heino | Director | Sale of securities on an exchange or to another person at price $ 86.93 per share. | 08 Nov 2024 | 400 | 447,036 (1%) | 0% | 86.9 | 34,772 | Common Stock |
| Julie Eastland | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 10 Sep 2024 | 1,345 | 1,345 (0%) | 0% | 0 | Common Stock | |
| Julie Eastland | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 10 Sep 2024 | 2,506 | 2,506 | - | - | Stock Option (right to buy) | |
| Robert J. Marshall | CFO and Treasurer | Payment of exercise price or tax liability using portion of securities received from the company at price $ 104.81 per share. | 29 Aug 2024 | 786 | 112,963 (0%) | 0% | 104.8 | 82,381 | Common Stock |
| James H. Thrall | Director | Sale of securities on an exchange or to another person at price $ 98.52 per share. | 21 Aug 2024 | 1,000 | 34,207 (0%) | 0% | 98.5 | 98,520 | Common Stock |
| Kimberly Brown | Chief Accounting Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 15 Aug 2024 | 8,398 | 8,398 | - | - | Stock Option (right to buy) | |
| Kimberly Brown | Chief Accounting Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 15 Aug 2024 | 4,731 | 4,731 (0%) | 0% | 0 | Common Stock | |
| Daniel M. Niedzwiecki | See Remarks | Sale of securities on an exchange or to another person at price $ 97.54 per share. | 14 Aug 2024 | 2,500 | 77,744 (0%) | 0% | 97.5 | 243,850 | Common Stock |
| Paul M. Blanchfield | President | Sale of securities on an exchange or to another person at price $ 96.39 per share. | 08 Aug 2024 | 2,000 | 98,980 (0%) | 0% | 96.4 | 192,780 | Common Stock |
| Mary Anne Heino | Director | Sale of securities on an exchange or to another person at price $ 96.68 per share. | 02 Aug 2024 | 96 | 454,923 (1%) | 0% | 96.7 | 9,281 | Common Stock |
| Mary Anne Heino | Director | Sale of securities on an exchange or to another person at price $ 96.01 per share. | 02 Aug 2024 | 3,661 | 455,019 (1%) | 0% | 96.0 | 351,492 | Common Stock |
| Mary Anne Heino | Director | Sale of securities on an exchange or to another person at price $ 95.20 per share. | 02 Aug 2024 | 6,724 | 458,680 (1%) | 0% | 95.2 | 640,127 | Common Stock |
| Paul M. Blanchfield | President | Payment of exercise price or tax liability using portion of securities received from the company at price $ 123.19 per share. | 15 Jul 2024 | 518 | 100,980 (0%) | 0% | 123.2 | 63,812 | Common Stock |
| Andrea Sabens | Chief Accounting Officer | Sale of securities on an exchange or to another person at price $ 123.15 per share. | 15 Jul 2024 | 341 | 62,216 (0%) | 0% | 123.1 | 41,994 | Common Stock |
| Andrea Sabens | Chief Accounting Officer | Sale of securities on an exchange or to another person at price $ 124.96 per share. | 15 Jul 2024 | 1,796 | 60,420 (0%) | 0% | 125.0 | 224,423 | Common Stock |
| Gary John Pruden | Director | Sale of securities on an exchange or to another person at price $ 95.04 per share. | 10 Jul 2024 | 12,530 | 11,978 (0%) | 0% | 95.0 | 1,190,851 | Common Stock |
| Jeffrey S. Humphrey | Chief Medical Officer | Grant, award, or other acquisition of securities at price $ 82.63 per share. | 17 Jun 2024 | 9,076 | 9,076 (0%) | 0% | 82.6 | 749,950 | Common Stock |
| Jeffrey S. Humphrey | Chief Medical Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 17 Jun 2024 | 16,188 | 16,188 | - | - | Stock Option (right to buy) | |
| Andrea Sabens | Chief Accounting Officer | Sale of securities on an exchange or to another person at price $ 79.77 per share. | 13 Jun 2024 | 341 | 62,557 (0%) | 0% | 79.8 | 27,202 | Common Stock |
| Mary Anne Heino | Director | Sale of securities on an exchange or to another person at price $ 81.00 per share. | 07 Jun 2024 | 1 | 37,719 (0%) | 0% | 81 | 81 | Common Stock |
| Mary Anne Heino | Director | Sale of securities on an exchange or to another person at price $ 100.00 per share. | 07 Jun 2024 | 2 | 8,618 (0%) | 0% | 100 | 200 | Common Stock |
| Mary Anne Heino | Director | Gift of securities by or to the insider at price $ 0.00 per share. | 07 Jun 2024 | 8,618 | 0 (0%) | 0% | 0 | Common Stock | |
| Mary Anne Heino | Director | Gift of securities by or to the insider at price $ 0.00 per share. | 07 Jun 2024 | 8,618 | 8,618 (0%) | 0% | 0 | Common Stock | |
| Paul M. Blanchfield | President | Sale of securities on an exchange or to another person at price $ 80.82 per share. | 31 May 2024 | 1,179 | 101,498 (0%) | 0% | 80.8 | 95,287 | Common Stock |
| Daniel M. Niedzwiecki | See Remarks | Sale of securities on an exchange or to another person at price $ 79.86 per share. | 30 May 2024 | 12,873 | 80,244 (0%) | 0% | 79.9 | 1,028,038 | Common Stock |
| Julie H. McHugh | Director | Sale of securities on an exchange or to another person at price $ 78.50 per share. | 28 May 2024 | 2,500 | 28,617 (0%) | 0% | 78.5 | 196,250 | Common Stock |
| Gary John Pruden | Director | Gift of securities by or to the insider at price $ 0.00 per share. | 20 May 2024 | 2,012 | 2,635 (0%) | 0% | 0 | Common Stock | |
| Daniel M. Niedzwiecki | See Remarks | Payment of exercise price or tax liability using portion of securities received from the company at price $ 79.67 per share. | 17 May 2024 | 1,466 | 93,117 (0%) | 0% | 79.7 | 116,796 | Common Stock |
| Andrea Sabens | Chief Accounting Officer | Sale of securities on an exchange or to another person at price $ 76.89 per share. | 13 May 2024 | 341 | 62,898 (0%) | 0% | 76.9 | 26,219 | Common Stock |
| James H. Thrall | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 09 May 2024 | 4,853 | 4,853 | - | - | Stock Option (right to buy) | |
| James H. Thrall | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 09 May 2024 | 2,635 | 35,207 (0%) | 0% | 0 | Common Stock | |
| Samuel R. Leno | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 09 May 2024 | 4,853 | 4,853 | - | - | Stock Option (right to buy) | |
| Samuel R. Leno | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 09 May 2024 | 2,635 | 60,572 (0%) | 0% | 0 | Common Stock | |
| Mary Anne Heino | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 09 May 2024 | 2,635 | 424,144 (1%) | 0% | 0 | Common Stock | |
| Mary Anne Heino | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 09 May 2024 | 4,853 | 4,853 | - | - | Stock Option (right to buy) | |
| Julie H. McHugh | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 09 May 2024 | 2,635 | 31,117 (0%) | 0% | 0 | Common Stock | |
| Julie H. McHugh | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 09 May 2024 | 4,853 | 4,853 | - | - | Stock Option (right to buy) | |
| Gary John Pruden | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 09 May 2024 | 2,635 | 35,592 (0%) | 0% | 0 | Common Stock | |
| Gary John Pruden | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 09 May 2024 | 4,853 | 4,853 | - | - | Stock Option (right to buy) | |
| Minnie V. Baylor-Henry | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 09 May 2024 | 2,635 | 7,344 (0%) | 0% | 0 | Common Stock | |
| Minnie V. Baylor-Henry | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 09 May 2024 | 4,853 | 4,853 | - | - | Stock Option (right to buy) | |
| Paul M. Blanchfield | President | Payment of exercise price or tax liability using portion of securities received from the company at price $ 61.48 per share. | 17 Apr 2024 | 455 | 102,677 (0%) | 0% | 61.5 | 27,973 | Common Stock |
| Daniel M. Niedzwiecki | See Remarks | Payment of exercise price or tax liability using portion of securities received from the company at price $ 61.48 per share. | 17 Apr 2024 | 177 | 94,583 (0%) | 0% | 61.5 | 10,882 | Common Stock |
| Andrea Sabens | Chief Accounting Officer | Sale of securities on an exchange or to another person at price $ 61.24 per share. | 15 Apr 2024 | 341 | 63,239 (0%) | 0% | 61.2 | 20,883 | Common Stock |
| Robert J. Marshall | CFO and Treasurer | Sale of securities on an exchange or to another person at price $ 60.00 per share. | 15 Mar 2024 | 20,000 | 113,749 (0%) | 0% | 60 | 1,200,000 | Common Stock |
| Andrea Sabens | Chief Accounting Officer | Sale of securities on an exchange or to another person at price $ 60.48 per share. | 13 Mar 2024 | 341 | 63,204 (0%) | 0% | 60.5 | 20,624 | Common Stock |
| Paul M. Blanchfield | President | Sale of securities on an exchange or to another person at price $ 61.96 per share. | 07 Mar 2024 | 18,023 | 103,357 (0%) | 0% | 62.0 | 1,116,705 | Common Stock |
| Paul M. Blanchfield | President | Gift of securities by or to the insider at price $ 0.00 per share. | 07 Mar 2024 | 500 | 102,857 (0%) | 0% | 0 | Common Stock | |
| Samuel R. Leno | Director | Sale of securities on an exchange or to another person at price $ 65.44 per share. | 05 Mar 2024 | 316 | 57,937 (0%) | 0% | 65.4 | 20,679 | Common Stock |
| Samuel R. Leno | Director | Sale of securities on an exchange or to another person at price $ 63.26 per share. | 05 Mar 2024 | 400 | 59,053 (0%) | 0% | 63.3 | 25,304 | Common Stock |
| Samuel R. Leno | Director | Sale of securities on an exchange or to another person at price $ 64.47 per share. | 05 Mar 2024 | 1,729 | 58,253 (0%) | 0% | 64.5 | 111,469 | Common Stock |
| Samuel R. Leno | Director | Exercise or conversion of derivative security received from the company (such as an option) at price $ 16.30 per share. | 05 Mar 2024 | 2,045 | 59,982 (0%) | 0% | 16.3 | 33,334 | Common Stock |
| Samuel R. Leno | Director | Sale of securities on an exchange or to another person at price $ 62.12 per share. | 05 Mar 2024 | 529 | 59,453 (0%) | 0% | 62.1 | 32,861 | Common Stock |
| Samuel R. Leno | Director | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 05 Mar 2024 | 2,045 | 0 | - | - | Stock Option (right to buy) | |
| Samuel R. Leno | Director | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 05 Mar 2024 | 2,045 | 0 | - | - | Stock Option (right to buy) | |
| Samuel R. Leno | Director | Sale of securities on an exchange or to another person at price $ 64.24 per share. | 05 Mar 2024 | 1,116 | 57,937 (0%) | 0% | 64.2 | 71,692 | Common Stock |
| Samuel R. Leno | Director | Exercise or conversion of derivative security received from the company (such as an option) at price $ 16.30 per share. | 05 Mar 2024 | 2,045 | 59,982 (0%) | 0% | 16.3 | 33,334 | Common Stock |
| Robert J. Marshall | CFO and Treasurer | Payment of exercise price or tax liability using portion of securities received from the company at price $ 65.36 per share. | 05 Mar 2024 | 35,730 | 133,749 (0%) | 0% | 65.4 | 2,335,313 | Common Stock |
| Etienne Montagut | Chief Business Officer | Payment of exercise price or tax liability using portion of securities received from the company at price $ 65.36 per share. | 05 Mar 2024 | 25,574 | 94,651 (0%) | 0% | 65.4 | 1,671,517 | Common Stock |
| Paul M. Blanchfield | President | Payment of exercise price or tax liability using portion of securities received from the company at price $ 65.36 per share. | 05 Mar 2024 | 20,728 | 121,380 (0%) | 0% | 65.4 | 1,354,782 | Common Stock |
| Daniel M. Niedzwiecki | See Remarks | Payment of exercise price or tax liability using portion of securities received from the company at price $ 65.36 per share. | 05 Mar 2024 | 8,457 | 94,760 (0%) | 0% | 65.4 | 552,750 | Common Stock |
| Andrea Sabens | Chief Accounting Officer | Payment of exercise price or tax liability using portion of securities received from the company at price $ 65.36 per share. | 05 Mar 2024 | 6,360 | 63,545 (0%) | 0% | 65.4 | 415,690 | Common Stock |
| Jean-Claude Provost | Chief Medical Officer | Payment of exercise price or tax liability using portion of securities received from the company at price $ 65.36 per share. | 05 Mar 2024 | 546 | 38,841 (0%) | 0% | 65.4 | 35,687 | Common Stock |
| Mary Anne Heino | Director | Sale of securities on an exchange or to another person at price $ 64.81 per share. | 04 Mar 2024 | 34,512 | 310,994 (0%) | 0% | 64.8 | 2,236,750 | Common Stock |
| Mary Anne Heino | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 04 Mar 2024 | 81,169 | 345,506 (0%) | 0% | 0 | Common Stock | |
| Mary Anne Heino | Director | Sale of securities on an exchange or to another person at price $ 66.23 per share. | 04 Mar 2024 | 100 | 251,643 (0%) | 0% | 66.2 | 6,623 | Common Stock |
| Mary Anne Heino | Director | Sale of securities on an exchange or to another person at price $ 65.59 per share. | 04 Mar 2024 | 59,251 | 251,743 (0%) | 0% | 65.6 | 3,886,516 | Common Stock |
| Samuel R. Leno | Director | Exercise or conversion of derivative security received from the company (such as an option) at price $ 16.30 per share. | 04 Mar 2024 | 2,045 | 59,982 (0%) | 0% | 16.3 | 33,334 | Common Stock |
| Samuel R. Leno | Director | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 04 Mar 2024 | 4,068 | 0 | - | - | Stock Option (right to buy) | |
| Samuel R. Leno | Director | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 04 Mar 2024 | 8,333 | 0 | - | - | Stock Option (right to buy) | |
| Samuel R. Leno | Director | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 04 Mar 2024 | 7,943 | 0 | - | - | Stock Option (right to buy) | |
| Samuel R. Leno | Director | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 04 Mar 2024 | 2,045 | 0 | - | - | Stock Option (right to buy) | |
| Samuel R. Leno | Director | Sale of securities on an exchange or to another person at price $ 65.60 per share. | 04 Mar 2024 | 17,364 | 57,937 (0%) | 0% | 65.6 | 1,139,078 | Common Stock |
| Samuel R. Leno | Director | Sale of securities on an exchange or to another person at price $ 64.81 per share. | 04 Mar 2024 | 5,025 | 75,301 (0%) | 0% | 64.8 | 325,670 | Common Stock |
| Samuel R. Leno | Director | Exercise or conversion of derivative security received from the company (such as an option) at price $ 64.20 per share. | 04 Mar 2024 | 4,068 | 80,326 (0%) | 0% | 64.2 | 261,166 | Common Stock |
| Samuel R. Leno | Director | Exercise or conversion of derivative security received from the company (such as an option) at price $ 6.00 per share. | 04 Mar 2024 | 8,333 | 76,258 (0%) | 0% | 6 | 49,998 | Common Stock |
| Samuel R. Leno | Director | Exercise or conversion of derivative security received from the company (such as an option) at price $ 12.59 per share. | 04 Mar 2024 | 7,943 | 67,925 (0%) | 0% | 12.6 | 100,002 | Common Stock |
| Brian A. Markison | Director, CEO | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 01 Mar 2024 | 131,496 | 152,826 (0%) | 0% | 0 | Common Stock | |
| Robert J. Marshall | CFO and Treasurer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 01 Mar 2024 | 29,762 | 169,479 (0%) | 0% | 0 | Common Stock | |
| Robert J. Marshall | CFO and Treasurer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 01 Mar 2024 | 21,652 | 21,652 | - | - | Stock Option (right to buy) | |
| Robert J. Marshall | CFO and Treasurer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 01 Mar 2024 | 36,547 | 139,717 (0%) | 0% | 0 | Common Stock | |
| Etienne Montagut | Chief Business Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 01 Mar 2024 | 18,559 | 18,559 | - | - | Stock Option (right to buy) | |
| Etienne Montagut | Chief Business Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 01 Mar 2024 | 31,326 | 98,580 (0%) | 0% | 0 | Common Stock | |
| Etienne Montagut | Chief Business Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 01 Mar 2024 | 21,645 | 120,225 (0%) | 0% | 0 | Common Stock | |
| Paul M. Blanchfield | President | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 01 Mar 2024 | 16,910 | 142,108 (0%) | 0% | 0 | Common Stock | |
| Paul M. Blanchfield | President | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 01 Mar 2024 | 36,547 | 125,198 (0%) | 0% | 0 | Common Stock | |
| Paul M. Blanchfield | President | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 01 Mar 2024 | 21,652 | 21,652 | - | - | Stock Option (right to buy) | |
| Daniel M. Niedzwiecki | See Remarks | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 01 Mar 2024 | 18,043 | 18,043 | - | - | Stock Option (right to buy) | |
| Daniel M. Niedzwiecki | See Remarks | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 01 Mar 2024 | 6,466 | 103,217 (0%) | 0% | 0 | Common Stock | |
| Daniel M. Niedzwiecki | See Remarks | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 01 Mar 2024 | 30,456 | 96,751 (0%) | 0% | 0 | Common Stock | |
| Andrea Sabens | Chief Accounting Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 01 Mar 2024 | 3,368 | 3,368 | - | - | Stock Option (right to buy) | |
| Andrea Sabens | Chief Accounting Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 01 Mar 2024 | 5,817 | 69,905 (0%) | 0% | 0 | Common Stock | |
| Andrea Sabens | Chief Accounting Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 01 Mar 2024 | 5,685 | 64,088 (0%) | 0% | 0 | Common Stock | |
| Jean-Claude Provost | Chief Medical Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 01 Mar 2024 | 10,998 | 10,998 | - | - | Stock Option (right to buy) | |
| Jean-Claude Provost | Chief Medical Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 01 Mar 2024 | 18,564 | 39,387 (0%) | 0% | 0 | Common Stock | |
| Andrea Sabens | Chief Accounting Officer | Sale of securities on an exchange or to another person at price $ 55.31 per share. | 13 Feb 2024 | 341 | 58,403 (0%) | 0% | 55.3 | 18,861 | Common Stock |
| Sabens Andrea | Chief Accounting Officer | Sale of securities on an exchange or to another person at price $ 56.01 per share. | 16 Jan 2024 | 341 | 58,744 (0%) | 0% | 56.0 | 19,099 | Common Stock |
| Robert J. Marshall | CFO and Treasurer | Sale of securities on an exchange or to another person at price $ 78.24 per share. | 15 Dec 2023 | 10,000 | 103,170 (0%) | 0% | 78.2 | 782,400 | Common Stock |
| Mary Anne Heino | Director, CEO | Gift of securities by or to the insider at price $ 0.00 per share. | 13 Dec 2023 | 53,350 | 264,337 (0%) | 0% | 0 | Common Stock | |
| Sabens Andrea | Chief Accounting Officer | Sale of securities on an exchange or to another person at price $ 75.62 per share. | 13 Dec 2023 | 341 | 59,085 (0%) | 0% | 75.6 | 25,786 | Common Stock |
| Paul M. Blanchfield | President | Sale of securities on an exchange or to another person at price $ 67.96 per share. | 16 Nov 2023 | 1,500 | 88,651 (0%) | 0% | 68.0 | 101,940 | Common Stock |
| Mary Anne Heino | Director, CEO | Sale of securities on an exchange or to another person at price $ 64.12 per share. | 13 Nov 2023 | 5,868 | 317,687 (0%) | 0% | 64.1 | 376,269 | Common Stock |
| Mary Anne Heino | Director, CEO | Sale of securities on an exchange or to another person at price $ 63.32 per share. | 13 Nov 2023 | 5,912 | 323,555 (0%) | 0% | 63.3 | 374,342 | Common Stock |
| Andrea Sabens | Chief Accounting Officer | Sale of securities on an exchange or to another person at price $ 63.57 per share. | 13 Nov 2023 | 341 | 59,426 (0%) | 0% | 63.6 | 21,677 | Common Stock |
| Daniel M. Niedzwiecki | See Remarks | Sale of securities on an exchange or to another person at price $ 66.43 per share. | 15 Sep 2023 | 2,846 | 66,295 (0%) | 0% | 66.4 | 189,060 | Common Stock |
| Daniel M. Niedzwiecki | See Remarks | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 15 Sep 2023 | 2,846 | 0 | - | - | Stock Option (right to buy) | |
| Daniel M. Niedzwiecki | See Remarks | Exercise or conversion of derivative security received from the company (such as an option) at price $ 17.79 per share. | 15 Sep 2023 | 2,846 | 69,141 (0%) | 0% | 17.8 | 50,630 | Common Stock |
| Robert J. Marshall | CFO and Treasurer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 29 Aug 2023 | 4,872 | 113,170 (0%) | 0% | 0 | Common Stock | |
| Paul M. Blanchfield | President | Sale of securities on an exchange or to another person at price $ 66.10 per share. | 21 Aug 2023 | 408 | 90,067 (0%) | 0% | 66.1 | 26,969 | Common Stock |
| Paul M. Blanchfield | President | Sale of securities on an exchange or to another person at price $ 65.19 per share. | 18 Aug 2023 | 1,500 | 90,475 (0%) | 0% | 65.2 | 97,785 | Common Stock |
| Robert J. Marshall | CFO and Treasurer | Sale of securities on an exchange or to another person at price $ 68.52 per share. | 15 Aug 2023 | 10,000 | 108,298 (0%) | 0% | 68.5 | 685,200 | Common Stock |
| Mary Anne Heino | Director, CEO | Sale of securities on an exchange or to another person at price $ 68.22 per share. | 11 Aug 2023 | 4,428 | 335,989 (0%) | 0% | 68.2 | 302,098 | Common Stock |
| Mary Anne Heino | Director, CEO | Sale of securities on an exchange or to another person at price $ 68.83 per share. | 11 Aug 2023 | 6,522 | 329,467 (0%) | 0% | 68.8 | 448,884 | Common Stock |
| Daniel M. Niedzwiecki | See Remarks | Sale of securities on an exchange or to another person at price $ 67.93 per share. | 11 Aug 2023 | 4,297 | 66,295 (0%) | 0% | 67.9 | 291,895 | Common Stock |
| Andrea Sabens | Chief Accounting Officer | Sale of securities on an exchange or to another person at price $ 90.87 per share. | 19 Jul 2023 | 1,752 | 59,767 (0%) | 0% | 90.9 | 159,209 | Common Stock |
| Paul M. Blanchfield | President | Payment of exercise price or tax liability using portion of securities received from the company at price $ 87.40 per share. | 18 Jul 2023 | 518 | 91,975 (0%) | 0% | 87.4 | 45,273 | Common Stock |
| Paul M. Blanchfield | President | Sale of securities on an exchange or to another person at price $ 97.93 per share. | 18 May 2023 | 1,500 | 92,743 (0%) | 0% | 97.9 | 146,895 | Common Stock |
| Paul M. Blanchfield | President | Gift of securities by or to the insider at price $ 0.00 per share. | 18 May 2023 | 250 | 92,493 (0%) | 0% | 0 | Common Stock | |
| Daniel M. Niedzwiecki | See Remarks | Payment of exercise price or tax liability using portion of securities received from the company at price $ 97.97 per share. | 18 May 2023 | 1,466 | 70,592 (0%) | 0% | 98.0 | 143,624 | Common Stock |
| Robert J. Marshall | CFO and Treasurer | Sale of securities on an exchange or to another person at price $ 99.36 per share. | 15 May 2023 | 10,000 | 118,298 (0%) | 0% | 99.4 | 993,600 | Common Stock |
| Andrea Sabens | Chief Accounting Officer | Sale of securities on an exchange or to another person at price $ 99.36 per share. | 15 May 2023 | 385 | 61,519 (0%) | 0% | 99.4 | 38,254 | Common Stock |
| Brian A. Markison | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 11 May 2023 | 3,798 | 3,798 | - | - | Stock Option (right to buy) | |
| Brian A. Markison | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 11 May 2023 | 2,012 | 21,330 (0%) | 0% | 0 | Common Stock | |
| James H. Thrall | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 11 May 2023 | 2,012 | 32,572 (0%) | 0% | 0 | Common Stock | |
| James H. Thrall | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 11 May 2023 | 3,798 | 3,798 | - | - | Stock Option (right to buy) | |
| Samuel R. Leno | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 11 May 2023 | 2,012 | 57,937 (0%) | 0% | 0 | Common Stock | |
| Samuel R. Leno | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 11 May 2023 | 3,798 | 3,798 | - | - | Stock Option (right to buy) | |
| Julie H. McHugh | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 11 May 2023 | 3,798 | 3,798 | - | - | Stock Option (right to buy) | |
| Julie H. McHugh | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 11 May 2023 | 2,012 | 28,482 (0%) | 0% | 0 | Common Stock | |
| Gary J. Pruden | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 11 May 2023 | 2,012 | 32,957 (0%) | 0% | 0 | Common Stock | |
| Gary J. Pruden | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 11 May 2023 | 3,798 | 3,798 | - | - | Stock Option (right to buy) | |
| Minnie V. Baylor-Henry | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 11 May 2023 | 3,798 | 3,798 | - | - | Stock Option (right to buy) | |
| Minnie V. Baylor-Henry | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 11 May 2023 | 2,012 | 4,709 (0%) | 0% | 0 | Common Stock | |
| Daniel M. Niedzwiecki | See Remarks | Sale of securities on an exchange or to another person at price $ 98.82 per share. | 11 May 2023 | 6,113 | 72,058 (0%) | 0% | 98.8 | 604,087 | Common Stock |
| Etienne Montagut | Chief Business Officer | Sale of securities on an exchange or to another person at price $ 88.67 per share. | 17 Apr 2023 | 2,118 | 67,254 (0%) | 0% | 88.7 | 187,803 | Common Stock |
| Paul M. Blanchfield | See Remarks | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 17 Apr 2023 | 5,025 | 5,025 | - | - | Stock Option (right to buy) | |
| Paul M. Blanchfield | See Remarks | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 17 Apr 2023 | 8,464 | 95,028 (0%) | 0% | 0 | Common Stock | |
| Daniel M. Niedzwiecki | See Remarks | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 17 Apr 2023 | 1,960 | 1,960 | - | - | Stock Option (right to buy) | |
| Daniel M. Niedzwiecki | See Remarks | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 17 Apr 2023 | 3,301 | 78,171 (0%) | 0% | 0 | Common Stock | |
| Andrea Sabens | Chief Accounting Officer | Sale of securities on an exchange or to another person at price $ 88.67 per share. | 17 Apr 2023 | 386 | 61,904 (0%) | 0% | 88.7 | 34,227 | Common Stock |
| Etienne Montagut | Chief Business Officer | Sale of securities on an exchange or to another person at price $ 82.09 per share. | 03 Apr 2023 | 3,684 | 69,372 (0%) | 0% | 82.1 | 302,420 | Common Stock |
| Brian A. Markison | Director | Sale of securities on an exchange or to another person at price $ 81.13 per share. | 27 Mar 2023 | 13,290 | 19,318 (0%) | 0% | 81.1 | 1,078,218 | Common Stock |
| Samuel R. Leno | Director | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 27 Mar 2023 | 7,012 | 0 | - | - | Stock Option (right to buy) | |
| Samuel R. Leno | Director | Exercise or conversion of derivative security received from the company (such as an option) at price $ 19.11 per share. | 27 Mar 2023 | 7,012 | 62,937 (0%) | 0% | 19.1 | 133,999 | Common Stock |
| Samuel R. Leno | Director | Sale of securities on an exchange or to another person at price $ 80.46 per share. | 27 Mar 2023 | 4,675 | 58,262 (0%) | 0% | 80.5 | 376,165 | Common Stock |
| Samuel R. Leno | Director | Sale of securities on an exchange or to another person at price $ 81.32 per share. | 27 Mar 2023 | 2,337 | 55,925 (0%) | 0% | 81.3 | 190,035 | Common Stock |
| Mary Anne Heino | Director, CEO | Sale of securities on an exchange or to another person at price $ 80.47 per share. | 27 Mar 2023 | 28,662 | 435,219 (1%) | 0% | 80.5 | 2,306,526 | Common Stock |
| Mary Anne Heino | Director, CEO | Sale of securities on an exchange or to another person at price $ 81.30 per share. | 27 Mar 2023 | 15,822 | 419,397 (1%) | 0% | 81.3 | 1,286,330 | Common Stock |
| Mary Anne Heino | Director, CEO | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 27 Mar 2023 | 44,484 | 0 | - | - | Stock Option (right to buy) | |
| Mary Anne Heino | Director, CEO | Exercise or conversion of derivative security received from the company (such as an option) at price $ 19.11 per share. | 27 Mar 2023 | 44,484 | 463,881 (1%) | 0% | 19.1 | 850,089 | Common Stock |
| Etienne Montagut | Chief Business Officer | Sale of securities on an exchange or to another person at price $ 81.13 per share. | 27 Mar 2023 | 14,528 | 73,056 (0%) | 0% | 81.1 | 1,178,657 | Common Stock |
| Robert J. Marshall | CFO and Treasurer | Sale of securities on an exchange or to another person at price $ 71.58 per share. | 15 Mar 2023 | 5,000 | 128,298 (0%) | 0% | 71.6 | 357,900 | Common Stock |
| Andrea Sabens | Chief Accounting Officer | Sale of securities on an exchange or to another person at price $ 71.58 per share. | 15 Mar 2023 | 386 | 62,290 (0%) | 0% | 71.6 | 27,630 | Common Stock |
| Mary Anne Heino | Director, President & CEO | Sale of securities on an exchange or to another person at price $ 75.29 per share. | 08 Mar 2023 | 4,744 | 719,397 (1%) | 0% | 75.3 | 357,169 | Common Stock |
| Mary Anne Heino | Director, President & CEO | Sale of securities on an exchange or to another person at price $ 74.18 per share. | 08 Mar 2023 | 5,320 | 724,141 (1%) | 0% | 74.2 | 394,624 | Common Stock |
| Robert J. Marshall | CFO and Treasurer | Sale of securities on an exchange or to another person at price $ 72.15 per share. | 06 Mar 2023 | 4,854 | 133,298 (0%) | 0% | 72.2 | 350,236 | Common Stock |
| Robert J. Marshall | CFO and Treasurer | Sale of securities on an exchange or to another person at price $ 72.56 per share. | 06 Mar 2023 | 20,587 | 138,152 (0%) | 0% | 72.6 | 1,493,813 | Common Stock |
| Etienne Montagut | Chief Business Officer | Sale of securities on an exchange or to another person at price $ 72.15 per share. | 06 Mar 2023 | 3,531 | 87,294 (0%) | 0% | 72.2 | 254,776 | Common Stock |
| Etienne Montagut | Chief Business Officer | Sale of securities on an exchange or to another person at price $ 72.56 per share. | 06 Mar 2023 | 14,179 | 90,825 (0%) | 0% | 72.6 | 1,028,842 | Common Stock |
| Paul M. Blanchfield | Chief Operating Officer | Sale of securities on an exchange or to another person at price $ 72.56 per share. | 06 Mar 2023 | 5,250 | 89,101 (0%) | 0% | 72.6 | 380,945 | Common Stock |
| Paul M. Blanchfield | Chief Operating Officer | Sale of securities on an exchange or to another person at price $ 72.15 per share. | 06 Mar 2023 | 2,758 | 86,343 (0%) | 0% | 72.2 | 199,001 | Common Stock |
| Daniel M. Niedzwiecki | See Remarks | Sale of securities on an exchange or to another person at price $ 72.15 per share. | 06 Mar 2023 | 1,055 | 74,870 (0%) | 0% | 72.2 | 76,122 | Common Stock |
| Daniel M. Niedzwiecki | See Remarks | Sale of securities on an exchange or to another person at price $ 72.56 per share. | 06 Mar 2023 | 9,079 | 75,925 (0%) | 0% | 72.6 | 658,781 | Common Stock |
| Andrea Sabens | Chief Accounting Officer | Sale of securities on an exchange or to another person at price $ 72.56 per share. | 06 Mar 2023 | 7,705 | 63,626 (0%) | 0% | 72.6 | 559,083 | Common Stock |
| Andrea Sabens | Chief Accounting Officer | Sale of securities on an exchange or to another person at price $ 72.15 per share. | 06 Mar 2023 | 950 | 62,676 (0%) | 0% | 72.2 | 68,546 | Common Stock |
| Mary Anne Heino | Director, President & CEO | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 02 Mar 2023 | 76,686 | 749,219 (1%) | 0% | 0 | Common Stock | |
| Mary Anne Heino | Director, President & CEO | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 02 Mar 2023 | 44,696 | 44,696 | - | - | Stock Option (right to buy) | |
| Mary Anne Heino | Director, President & CEO | Sale of securities on an exchange or to another person at price $ 73.24 per share. | 02 Mar 2023 | 12,189 | 729,461 (1%) | 0% | 73.2 | 892,771 | Common Stock |
| Mary Anne Heino | Director, President & CEO | Sale of securities on an exchange or to another person at price $ 73.35 per share. | 02 Mar 2023 | 17,397 | 741,650 (1%) | 0% | 73.4 | 1,276,112 | Common Stock |
| Mary Anne Heino | Director, President & CEO | Sale of securities on an exchange or to another person at price $ 72.90 per share. | 02 Mar 2023 | 64,658 | 759,047 (1%) | 0% | 72.9 | 4,713,542 | Common Stock |
| Mary Anne Heino | Director, President & CEO | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 02 Mar 2023 | 74,486 | 823,705 (2%) | 0% | 0 | Common Stock | |
| Robert J. Marshall | CFO and Treasurer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 02 Mar 2023 | 11,822 | 11,822 | - | - | Stock Option (right to buy) | |
| Robert J. Marshall | CFO and Treasurer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 02 Mar 2023 | 20,283 | 141,348 (0%) | 0% | 0 | Common Stock | |
| Robert J. Marshall | CFO and Treasurer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 02 Mar 2023 | 17,391 | 158,739 (0%) | 0% | 0 | Common Stock | |
| Etienne Montagut | Chief Business Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 02 Mar 2023 | 13,968 | 92,643 (0%) | 0% | 0 | Common Stock | |
| Etienne Montagut | Chief Business Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 02 Mar 2023 | 8,141 | 8,141 | - | - | Stock Option (right to buy) | |
| Etienne Montagut | Chief Business Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 02 Mar 2023 | 12,361 | 105,004 (0%) | 0% | 0 | Common Stock | |
| Paul M. Blanchfield | Chief Operating Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 02 Mar 2023 | 11,880 | 11,880 | - | - | Stock Option (right to buy) | |
| Paul M. Blanchfield | Chief Operating Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 02 Mar 2023 | 20,383 | 94,351 (0%) | 0% | 0 | Common Stock | |
| Daniel M. Niedzwiecki | See Remarks | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 02 Mar 2023 | 7,515 | 85,004 (0%) | 0% | 0 | Common Stock | |
| Daniel M. Niedzwiecki | See Remarks | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 02 Mar 2023 | 12,346 | 77,489 (0%) | 0% | 0 | Common Stock | |
| Daniel M. Niedzwiecki | See Remarks | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 02 Mar 2023 | 7,196 | 7,196 | - | - | Stock Option (right to buy) | |
| Andrea Sabens | Chief Accounting Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 02 Mar 2023 | 3,772 | 64,232 (0%) | 0% | 0 | Common Stock | |
| Andrea Sabens | Chief Accounting Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 02 Mar 2023 | 7,099 | 71,331 (0%) | 0% | 0 | Common Stock | |
| Andrea Sabens | Chief Accounting Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 02 Mar 2023 | 1,936 | 1,936 | - | - | Stock Option (right to buy) | |
| Jean-Claude Provost | Chief Medical Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 02 Mar 2023 | 9,535 | 9,535 | - | - | Stock Option (right to buy) | |
| Jean-Claude Provost | Chief Medical Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 02 Mar 2023 | 16,359 | 20,823 (0%) | 0% | 0 | Common Stock | |
| Andrea Sabens | Chief Accounting Officer | Sale of securities on an exchange or to another person at price $ 57.52 per share. | 15 Feb 2023 | 386 | 60,460 (0%) | 0% | 57.5 | 22,203 | Common Stock |
| Andrea Sabens | Chief Accounting Officer | Sale of securities on an exchange or to another person at price $ 52.97 per share. | 17 Jan 2023 | 386 | 60,846 (0%) | 0% | 53.0 | 20,446 | Common Stock |
| Andrea Sabens | Chief Accounting Officer | Sale of securities on an exchange or to another person at price $ 53.75 per share. | 15 Dec 2022 | 386 | 61,232 (0%) | 0% | 53.8 | 20,748 | Common Stock |
| Paul M. Blanchfield | Chief Operating Officer | Sale of securities on an exchange or to another person at price $ 54.79 per share. | 17 Nov 2022 | 2,432 | 73,968 (0%) | 0% | 54.8 | 133,249 | Common Stock |
| Robert J. Marshall | CFO and Treasurer | Sale of securities on an exchange or to another person at price $ 59.00 per share. | 15 Nov 2022 | 5,000 | 121,065 (0%) | 0% | 59 | 295,000 | Common Stock |
| Andrea Sabens | Chief Accounting Officer | Sale of securities on an exchange or to another person at price $ 59.00 per share. | 15 Nov 2022 | 386 | 61,618 (0%) | 0% | 59 | 22,774 | Common Stock |
| Daniel M. Niedzwiecki | See Remarks | Sale of securities on an exchange or to another person at price $ 59.73 per share. | 11 Nov 2022 | 3,000 | 65,143 (0%) | 0% | 59.7 | 179,190 | Common Stock |
| Mary Anne Heino | Director, President & CEO | Sale of securities on an exchange or to another person at price $ 55.94 per share. | 08 Nov 2022 | 2,000 | 683,683 (1%) | 0% | 55.9 | 111,877 | Common Stock |
| Mary Anne Heino | Director, President & CEO | Sale of securities on an exchange or to another person at price $ 58.58 per share. | 08 Nov 2022 | 1,516 | 672,533 (1%) | 0% | 58.6 | 88,803 | Common Stock |
| Mary Anne Heino | Director, President & CEO | Sale of securities on an exchange or to another person at price $ 57.86 per share. | 08 Nov 2022 | 4,884 | 674,049 (1%) | 0% | 57.9 | 282,570 | Common Stock |
| Mary Anne Heino | Director, President & CEO | Sale of securities on an exchange or to another person at price $ 56.66 per share. | 08 Nov 2022 | 4,750 | 678,933 (1%) | 0% | 56.7 | 269,115 | Common Stock |
| Robert J. Marshall | CFO and Treasurer | Sale of securities on an exchange or to another person at price $ 73.41 per share. | 18 Oct 2022 | 4,828 | 126,065 (0%) | 0% | 73.4 | 354,443 | Common Stock |
| Etienne Montagut | Chief Business Officer | Sale of securities on an exchange or to another person at price $ 71.81 per share. | 18 Oct 2022 | 3,324 | 78,675 (0%) | 0% | 71.8 | 238,696 | Common Stock |
| Etienne Montagut | Chief Business Officer | Sale of securities on an exchange or to another person at price $ 73.41 per share. | 18 Oct 2022 | 2,536 | 81,999 (0%) | 0% | 73.4 | 186,178 | Common Stock |
| Andrea Sabens | Chief Accounting Officer | Sale of securities on an exchange or to another person at price $ 70.50 per share. | 17 Oct 2022 | 386 | 62,004 (0%) | 0% | 70.5 | 27,213 | Common Stock |
| Andrea Sabens | Chief Accounting Officer | Sale of securities on an exchange or to another person at price $ 85.83 per share. | 15 Sep 2022 | 386 | 62,390 (0%) | 0% | 85.8 | 33,130 | Common Stock |
| Brian A. Markison | Director | Exercise or conversion of derivative security received from the company (such as an option) at price $ 19.11 per share. | 08 Sep 2022 | 9,464 | 62,695 (0%) | 0% | 19.1 | 180,857 | Common Stock |
| Brian A. Markison | Director | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 08 Sep 2022 | 11,725 | 0 | - | - | Stock Option (right to buy) | |
| Brian A. Markison | Director | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 08 Sep 2022 | 9,464 | 0 | - | - | Stock Option (right to buy) | |
| Brian A. Markison | Director | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 08 Sep 2022 | 3,263 | 0 | - | - | Stock Option (right to buy) | |
| Brian A. Markison | Director | Sale of securities on an exchange or to another person at price $ 84.84 per share. | 08 Sep 2022 | 13,788 | 32,608 (0%) | 0% | 84.8 | 1,169,785 | Common Stock |
| Brian A. Markison | Director | Sale of securities on an exchange or to another person at price $ 84.10 per share. | 08 Sep 2022 | 23,852 | 46,396 (0%) | 0% | 84.1 | 2,006,044 | Common Stock |
| Brian A. Markison | Director | Sale of securities on an exchange or to another person at price $ 83.05 per share. | 08 Sep 2022 | 4,172 | 70,248 (0%) | 0% | 83.0 | 346,464 | Common Stock |
| Brian A. Markison | Director | Exercise or conversion of derivative security received from the company (such as an option) at price $ 17.06 per share. | 08 Sep 2022 | 11,725 | 74,420 (0%) | 0% | 17.1 | 200,029 | Common Stock |
| Brian A. Markison | Director | Exercise or conversion of derivative security received from the company (such as an option) at price $ 21.13 per share. | 08 Sep 2022 | 3,263 | 53,231 (0%) | 0% | 21.1 | 68,947 | Common Stock |
| Brian A. Markison | Director | Sale of securities on an exchange or to another person at price $ 78.50 per share. | 06 Sep 2022 | 1,693 | 49,968 (0%) | 0% | 78.5 | 132,901 | Common Stock |
| Brian A. Markison | Director | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 06 Sep 2022 | 1,693 | 0 | - | - | Stock Option (right to buy) | |
| Brian A. Markison | Director | Exercise or conversion of derivative security received from the company (such as an option) at price $ 19.78 per share. | 06 Sep 2022 | 1,693 | 51,661 (0%) | 0% | 19.8 | 33,488 | Common Stock |
| Julie H. McHugh | Director | Sale of securities on an exchange or to another person at price $ 78.50 per share. | 06 Sep 2022 | 4,300 | 26,470 (0%) | 0% | 78.5 | 337,550 | Common Stock |
| Paul M. Blanchfield | Chief Operating Officer | Sale of securities on an exchange or to another person at price $ 83.39 per share. | 18 Aug 2022 | 1,500 | 76,143 (0%) | 0% | 83.4 | 125,085 | Common Stock |
| Robert J. Marshall | CFO and Treasurer | Sale of securities on an exchange or to another person at price $ 82.82 per share. | 15 Aug 2022 | 5,000 | 130,893 (0%) | 0% | 82.8 | 414,100 | Common Stock |
| Andrea Sabens | Chief Accounting Officer | Sale of securities on an exchange or to another person at price $ 82.82 per share. | 15 Aug 2022 | 386 | 62,776 (0%) | 0% | 82.8 | 31,969 | Common Stock |
| Daniel M. Niedzwiecki | See Remarks | Sale of securities on an exchange or to another person at price $ 82.66 per share. | 11 Aug 2022 | 3,000 | 68,143 (0%) | 0% | 82.7 | 247,980 | Common Stock |
| Mary Anne Heino | Director, President & CEO | Sale of securities on an exchange or to another person at price $ 80.05 per share. | 08 Aug 2022 | 4,260 | 685,883 (1%) | 0% | 80.0 | 341,007 | Common Stock |
| Mary Anne Heino | Director, President & CEO | Sale of securities on an exchange or to another person at price $ 80.83 per share. | 08 Aug 2022 | 200 | 685,683 (1%) | 0% | 80.8 | 16,166 | Common Stock |
| Mary Anne Heino | Director, President & CEO | Sale of securities on an exchange or to another person at price $ 79.34 per share. | 08 Aug 2022 | 4,972 | 690,143 (1%) | 0% | 79.3 | 394,485 | Common Stock |
| Paul M. Blanchfield | Chief Operating Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 15 Jul 2022 | 5,425 | 5,425 | - | - | Stock Option (right to buy) | |
| Paul M. Blanchfield | Chief Operating Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 15 Jul 2022 | 3,211 | 77,357 (0%) | 0% | 0 | Common Stock | |
| Andrea Sabens | Chief Accounting Officer | Sale of securities on an exchange or to another person at price $ 69.12 per share. | 15 Jul 2022 | 386 | 64,255 (0%) | 0% | 69.1 | 26,680 | Common Stock |
| Andrea Sabens | Chief Accounting Officer | Sale of securities on an exchange or to another person at price $ 71.47 per share. | 15 Jul 2022 | 1,093 | 63,162 (0%) | 0% | 71.5 | 78,115 | Common Stock |
| Andrea Sabens | Chief Accounting Officer | Sale of securities on an exchange or to another person at price $ 62.87 per share. | 15 Jun 2022 | 386 | 64,441 (0%) | 0% | 62.9 | 24,268 | Common Stock |
| Daniel M. Niedzwiecki | See Remarks | Sale of securities on an exchange or to another person at price $ 64.54 per share. | 18 May 2022 | 1,380 | 71,143 (0%) | 0% | 64.5 | 89,062 | Common Stock |
| Robert J. Marshall | CFO and Treasurer | Sale of securities on an exchange or to another person at price $ 63.27 per share. | 16 May 2022 | 10,000 | 135,893 (0%) | 0% | 63.3 | 632,700 | Common Stock |
| Paul M. Blanchfield | Chief Commercial Officer | Sale of securities on an exchange or to another person at price $ 60.95 per share. | 13 May 2022 | 2,285 | 74,146 (0%) | 0% | 61.0 | 139,271 | Common Stock |
| Paul M. Blanchfield | Chief Commercial Officer | Gift of securities by or to the insider at price $ 0.00 per share. | 13 May 2022 | 785 | 785 (0%) | 0% | 0 | Common Stock | |
| Julie H. McHugh | Director | Sale of securities on an exchange or to another person at price $ 57.84 per share. | 11 May 2022 | 2,980 | 30,770 (0%) | 0% | 57.8 | 172,363 | Common Stock |
| Brian A. Markison | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 06 May 2022 | 4,068 | 4,068 | - | - | Stock Option (right to buy) | |
| James H. Thrall | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 06 May 2022 | 4,068 | 4,068 | - | - | Stock Option (right to buy) | |
| Samuel R. Leno | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 06 May 2022 | 4,068 | 4,068 | - | - | Stock Option (right to buy) | |
| Julie H. McHugh | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 06 May 2022 | 4,068 | 4,068 | - | - | Stock Option (right to buy) | |
| Gary J. Pruden | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 06 May 2022 | 4,068 | 4,068 | - | - | Stock Option (right to buy) | |
| Minnie V. Baylor-Henry | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 06 May 2022 | 4,068 | 4,068 | - | - | Stock Option (right to buy) | |
| Etienne Montagut | Chief Business Officer | Sale of securities on an exchange or to another person at price $ 57.38 per share. | 04 Apr 2022 | 12,655 | 83,975 (0%) | 0% | 57.4 | 726,144 | Common Stock |
| Samuel R. Leno | Director | Exercise or conversion of derivative security received from the company (such as an option) at price $ 23.04 per share. | 31 Mar 2022 | 4,448 | 53,745 (0%) | 0% | 23.0 | 102,482 | Common Stock |
| Samuel R. Leno | Director | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 31 Mar 2022 | 4,448 | 0 | - | - | Stock Option (right to buy) | |
| Carol Walker | Senior Vice President, Quality | Sale of securities on an exchange or to another person at price $ 56.22 per share. | 30 Mar 2022 | 15,000 | 64,899 (0%) | 0% | 56.2 | 843,300 | Common Stock |
| Carol Walker | Senior Vice President, Quality | Sale of securities on an exchange or to another person at price $ 52.55 per share. | 07 Mar 2022 | 1,593 | 79,899 (0%) | 0% | 52.5 | 83,709 | Common Stock |
| Robert J. Marshall | CFO and Treasurer | Sale of securities on an exchange or to another person at price $ 52.55 per share. | 07 Mar 2022 | 4,380 | 145,893 (0%) | 0% | 52.5 | 230,160 | Common Stock |
| Etienne Montagut | Chief Business Officer | Sale of securities on an exchange or to another person at price $ 52.55 per share. | 07 Mar 2022 | 3,115 | 96,634 (0%) | 0% | 52.5 | 163,687 | Common Stock |
| Paul M. Blanchfield | Chief Commercial Officer | Sale of securities on an exchange or to another person at price $ 52.55 per share. | 07 Mar 2022 | 2,228 | 76,431 (0%) | 0% | 52.5 | 117,077 | Common Stock |
| Daniel M. Niedzwiecki | See Remarks | Sale of securities on an exchange or to another person at price $ 50.63 per share. | 07 Mar 2022 | 432 | 72,523 (0%) | 0% | 50.6 | 21,872 | Common Stock |
| Daniel M. Niedzwiecki | See Remarks | Sale of securities on an exchange or to another person at price $ 52.55 per share. | 07 Mar 2022 | 1,330 | 72,955 (0%) | 0% | 52.5 | 69,889 | Common Stock |
| Andrea Sabens | Chief Accounting Officer | Sale of securities on an exchange or to another person at price $ 50.63 per share. | 07 Mar 2022 | 391 | 65,027 (0%) | 0% | 50.6 | 19,796 | Common Stock |
| Andrea Sabens | Chief Accounting Officer | Sale of securities on an exchange or to another person at price $ 52.55 per share. | 07 Mar 2022 | 1,228 | 65,418 (0%) | 0% | 52.5 | 64,529 | Common Stock |
| Mary Anne Heino | Director, President & CEO | Sale of securities on an exchange or to another person at price $ 51.24 per share. | 03 Mar 2022 | 11,478 | 707,391 (1%) | 0% | 51.2 | 588,110 | Common Stock |
| Mary Anne Heino | Director, President & CEO | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 03 Mar 2022 | 42,822 | 42,822 | - | - | Stock Option (right to buy) | |
| Mary Anne Heino | Director, President & CEO | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 03 Mar 2022 | 75,105 | 730,739 (1%) | 0% | 0 | Common Stock | |
| Mary Anne Heino | Director, President & CEO | Sale of securities on an exchange or to another person at price $ 52.04 per share. | 03 Mar 2022 | 9,413 | 721,326 (1%) | 0% | 52.0 | 489,847 | Common Stock |
| Mary Anne Heino | Director, President & CEO | Sale of securities on an exchange or to another person at price $ 52.60 per share. | 03 Mar 2022 | 1,760 | 719,566 (1%) | 0% | 52.6 | 92,579 | Common Stock |
| Mary Anne Heino | Director, President & CEO | Sale of securities on an exchange or to another person at price $ 49.96 per share. | 03 Mar 2022 | 697 | 718,869 (1%) | 0% | 50.0 | 34,819 | Common Stock |
| Carol Walker | Senior Vice President, Quality | Sale of securities on an exchange or to another person at price $ 49.98 per share. | 03 Mar 2022 | 1,536 | 81,492 (0%) | 0% | 50.0 | 76,774 | Common Stock |
| Carol Walker | Senior Vice President, Quality | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 03 Mar 2022 | 4,239 | 4,239 | - | - | Stock Option (right to buy) | |
| Carol Walker | Senior Vice President, Quality | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 03 Mar 2022 | 7,434 | 83,028 (0%) | 0% | 0 | Common Stock | |
| Minnie V. Baylor-Henry | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 03 Mar 2022 | 517 | 517 (0%) | 0% | 0 | Common Stock | |
| Robert J. Marshall | CFO and Treasurer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 03 Mar 2022 | 25,911 | 152,843 (0%) | 0% | 0 | Common Stock | |
| Robert J. Marshall | CFO and Treasurer | Sale of securities on an exchange or to another person at price $ 49.98 per share. | 03 Mar 2022 | 2,570 | 150,273 (0%) | 0% | 50.0 | 128,456 | Common Stock |
| Robert J. Marshall | CFO and Treasurer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 03 Mar 2022 | 14,773 | 14,773 | - | - | Stock Option (right to buy) | |
| Etienne Montagut | Chief Business Officer | Sale of securities on an exchange or to another person at price $ 49.98 per share. | 03 Mar 2022 | 1,635 | 99,749 (0%) | 0% | 50.0 | 81,722 | Common Stock |
| Etienne Montagut | Chief Business Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 03 Mar 2022 | 10,174 | 10,174 | - | - | Stock Option (right to buy) | |
| Etienne Montagut | Chief Business Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 03 Mar 2022 | 17,844 | 101,384 (0%) | 0% | 0 | Common Stock | |
| Paul M. Blanchfield | Chief Commercial Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 03 Mar 2022 | 20,653 | 82,573 (0%) | 0% | 0 | Common Stock | |
| Paul M. Blanchfield | Chief Commercial Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 03 Mar 2022 | 11,776 | 11,776 | - | - | Stock Option (right to buy) | |
| Paul M. Blanchfield | Chief Commercial Officer | Sale of securities on an exchange or to another person at price $ 49.98 per share. | 03 Mar 2022 | 3,914 | 78,659 (0%) | 0% | 50.0 | 195,633 | Common Stock |
| Daniel M. Niedzwiecki | See Remarks | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 03 Mar 2022 | 8,992 | 8,992 | - | - | Stock Option (right to buy) | |
| Daniel M. Niedzwiecki | See Remarks | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 03 Mar 2022 | 15,771 | 74,285 (0%) | 0% | 0 | Common Stock | |
| Andrea Sabens | Chief Accounting Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 03 Mar 2022 | 2,954 | 2,954 | - | - | Stock Option (right to buy) | |
| Andrea Sabens | Chief Accounting Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 03 Mar 2022 | 5,481 | 66,646 (0%) | 0% | 0 | Common Stock | |
| Mary Anne Heino | Director, President & CEO | Sale of securities on an exchange or to another person at price $ 46.31 per share. | 28 Feb 2022 | 31,528 | 668,015 (1%) | 0% | 46.3 | 1,460,147 | Common Stock |
| Mary Anne Heino | Director, President & CEO | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 28 Feb 2022 | 38,794 | 699,543 (1%) | 0% | 0 | Common Stock | |
| Mary Anne Heino | Director, President & CEO | Sale of securities on an exchange or to another person at price $ 46.98 per share. | 28 Feb 2022 | 12,381 | 655,634 (1%) | 0% | 47.0 | 581,622 | Common Stock |
| Carol Walker | Senior Vice President, Quality | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 28 Feb 2022 | 6,181 | 82,550 (0%) | 0% | 0 | Common Stock | |
| Carol Walker | Senior Vice President, Quality | Sale of securities on an exchange or to another person at price $ 48.04 per share. | 28 Feb 2022 | 6,956 | 75,594 (0%) | 0% | 48.0 | 334,145 | Common Stock |
| Robert J. Marshall | CFO and Treasurer | Sale of securities on an exchange or to another person at price $ 48.04 per share. | 28 Feb 2022 | 8,851 | 126,932 (0%) | 0% | 48.0 | 425,175 | Common Stock |
| Robert J. Marshall | CFO and Treasurer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 28 Feb 2022 | 8,776 | 135,783 (0%) | 0% | 0 | Common Stock | |
| Etienne Montagut | Chief Business Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 28 Feb 2022 | 5,935 | 89,529 (0%) | 0% | 0 | Common Stock | |
| Etienne Montagut | Chief Business Officer | Sale of securities on an exchange or to another person at price $ 48.04 per share. | 28 Feb 2022 | 5,989 | 83,540 (0%) | 0% | 48.0 | 287,694 | Common Stock |
| Daniel M. Niedzwiecki | See Remarks | Sale of securities on an exchange or to another person at price $ 48.04 per share. | 28 Feb 2022 | 2,645 | 58,514 (0%) | 0% | 48.0 | 127,058 | Common Stock |
| Daniel M. Niedzwiecki | See Remarks | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 28 Feb 2022 | 4,099 | 61,159 (0%) | 0% | 0 | Common Stock | |
| Andrea Sabens | Chief Accounting Officer | Sale of securities on an exchange or to another person at price $ 48.04 per share. | 28 Feb 2022 | 2,409 | 61,165 (0%) | 0% | 48.0 | 115,721 | Common Stock |
| Andrea Sabens | Chief Accounting Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 28 Feb 2022 | 3,713 | 63,574 (0%) | 0% | 0 | Common Stock | |
| Andrea Sabens | Chief Accounting Officer | Sale of securities on an exchange or to another person at price $ 28.64 per share. | 15 Feb 2022 | 1,241 | 59,861 (0%) | 0% | 28.6 | 35,542 | Common Stock |
| Andrea Sabens | Chief Accounting Officer | Sale of securities on an exchange or to another person at price $ 26.93 per share. | 18 Jan 2022 | 1,242 | 61,102 (0%) | 0% | 26.9 | 33,447 | Common Stock |
| Vivian Ying Yao | Chief Human Resources Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 18 Jan 2022 | 6,423 | 6,423 | - | - | Stock Option (right to buy) | |
| Vivian Ying Yao | Chief Human Resources Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 18 Jan 2022 | 11,265 | 30,319 (0%) | 0% | 0 | Common Stock | |
| Vivian Ying Yao | Chief Human Resources Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 18 Jan 2022 | 19,054 | 19,054 (0%) | 0% | 0 | Common Stock | |
| Mary Anne Heino | Director, President & CEO | Sale of securities on an exchange or to another person at price $ 28.61 per share. | 03 Jan 2022 | 14,100 | 660,749 (1%) | 0% | 28.6 | 403,412 | Common Stock |
| Andrea Sabens | Chief Accounting Officer | Sale of securities on an exchange or to another person at price $ 26.72 per share. | 15 Dec 2021 | 1,242 | 62,344 (0%) | 0% | 26.7 | 33,186 | Common Stock |
| Andrea Sabens | Chief Accounting Officer | Sale of securities on an exchange or to another person at price $ 30.47 per share. | 15 Nov 2021 | 1,242 | 63,586 (0%) | 0% | 30.5 | 37,844 | Common Stock |
| Mary Anne Heino | Director, President & CEO | Sale of securities on an exchange or to another person at price $ 30.12 per share. | 10 Nov 2021 | 13,333 | 674,849 (1%) | 0% | 30.1 | 401,646 | Common Stock |
| Robert J. Marshall | CFO and Treasurer | Sale of securities on an exchange or to another person at price $ 22.90 per share. | 18 Oct 2021 | 4,502 | 132,007 (0%) | 0% | 22.9 | 103,082 | Common Stock |
| Robert J. Marshall | CFO and Treasurer | Sale of securities on an exchange or to another person at price $ 22.95 per share. | 18 Oct 2021 | 5,000 | 127,007 (0%) | 0% | 23.0 | 114,750 | Common Stock |
| Etienne Montagut | Chief Business Officer | Sale of securities on an exchange or to another person at price $ 22.90 per share. | 18 Oct 2021 | 2,364 | 85,342 (0%) | 0% | 22.9 | 54,129 | Common Stock |
| Etienne Montagut | Chief Business Officer | Sale of securities on an exchange or to another person at price $ 22.95 per share. | 18 Oct 2021 | 1,748 | 83,594 (0%) | 0% | 23.0 | 40,117 | Common Stock |
| Andrea Sabens | Chief Accounting Officer | Sale of securities on an exchange or to another person at price $ 23.71 per share. | 15 Oct 2021 | 1,242 | 64,828 (0%) | 0% | 23.7 | 29,448 | Common Stock |
| Andrea Sabens | Chief Accounting Officer | Sale of securities on an exchange or to another person at price $ 24.55 per share. | 15 Sep 2021 | 1,242 | 66,070 (0%) | 0% | 24.5 | 30,491 | Common Stock |
| Etienne Montagut | Chief Business Officer | Sale of securities on an exchange or to another person at price $ 26.06 per share. | 08 Sep 2021 | 457 | 87,262 (0%) | 0% | 26.1 | 11,909 | Common Stock |
| Daniel M. Niedzwiecki | See Remarks | Payment of exercise price or tax liability using portion of securities received from the company at price $ 24.98 per share. | 16 Aug 2021 | 243 | 57,060 (0%) | 0% | 25.0 | 6,070 | Common Stock |
| Andrea Sabens | Chief Accounting Officer | Sale of securities on an exchange or to another person at price $ 25.46 per share. | 16 Aug 2021 | 1,242 | 67,312 (0%) | 0% | 25.5 | 31,621 | Common Stock |
| Mary Anne Heino | Director, President & CEO | Sale of securities on an exchange or to another person at price $ 25.83 per share. | 10 Aug 2021 | 15,580 | 688,182 (1%) | 0% | 25.8 | 402,369 | Common Stock |
| John J. Bolla | Chief Operations Officer | Sale of securities on an exchange or to another person at price $ 24.37 per share. | 16 Jun 2021 | 2,253 | 102,440 (0%) | 0% | 24.4 | 54,912 | Common Stock |
| Etienne Montagut | Chief Business Officer | Sale of securities on an exchange or to another person at price $ 24.60 per share. | 04 Jun 2021 | 7,435 | 87,719 (0%) | 0% | 24.6 | 182,901 | Common Stock |
| Daniel M. Niedzwiecki | See Remarks | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 17 May 2021 | 9,093 | 57,303 (0%) | 0% | 0 | Common Stock | |
| Brian A. Markison | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 10 May 2021 | 8,513 | 47,788 (0%) | 0% | 0 | Common Stock | |
| James H. Thrall | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 10 May 2021 | 8,513 | 28,380 (0%) | 0% | 0 | Common Stock | |
| Samuel R. Leno | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 10 May 2021 | 8,513 | 49,297 (0%) | 0% | 0 | Common Stock | |
| Julie H. McHugh | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 10 May 2021 | 8,513 | 31,570 (0%) | 0% | 0 | Common Stock | |
| Gary J. Pruden | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 10 May 2021 | 8,513 | 28,765 (0%) | 0% | 0 | Common Stock | |
| Frederick A. Robertson | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 28 Apr 2021 | 1,139 | 51,798 (0%) | 0% | 0 | Common Stock | |
| Michael P. Duffy | SVP and General Counsel | Sale of securities on an exchange or to another person at price $ 21.75 per share. | 16 Apr 2021 | 7,500 | 109,472 (0%) | 0% | 21.8 | 163,125 | Common Stock |
| Mary Anne Heino | Director, President & CEO | Sale of securities on an exchange or to another person at price $ 20.66 per share. | 12 Apr 2021 | 19,421 | 703,762 (1%) | 0% | 20.7 | 401,277 | Common Stock |
| Julie H. McHugh | Director | Sale of securities on an exchange or to another person at price $ 21.22 per share. | 09 Apr 2021 | 2,800 | 23,057 (0%) | 0% | 21.2 | 59,416 | Common Stock |
| Samuel R. Leno | Director | Sale of securities on an exchange or to another person at price $ 21.17 per share. | 08 Apr 2021 | 5,000 | 40,784 (0%) | 0% | 21.2 | 105,840 | Common Stock |
| Mary Anne Heino | Director, President & CEO | Other type of transaction at price $ 19.47 per share. | 05 Mar 2021 | 11,464 | 723,184 (1%) | 0% | 19.5 | 223,157 | Common Stock |
| Mary Anne Heino | Director, President & CEO | Sale of securities on an exchange or to another person at price $ 18.26 per share. | 05 Mar 2021 | 27,157 | 711,720 (1%) | 0% | 18.3 | 495,838 | Common Stock |
| Mary Anne Heino | Director, President & CEO | Gift of securities by or to the insider at price $ 0.00 per share. | 04 Mar 2021 | 1,500 | 578,039 (1%) | 0% | 0 | Common Stock | |
| Mary Anne Heino | Director, President & CEO | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 04 Mar 2021 | 162,338 | 738,877 (1%) | 0% | 0 | Common Stock | |
| Mary Anne Heino | Director, President & CEO | Gift of securities by or to the insider at price $ 0.00 per share. | 04 Mar 2021 | 1,500 | 3,700 (0%) | 0% | 0 | Common Stock | |
| Mary Anne Heino | Director, President & CEO | Gift of securities by or to the insider at price $ 0.00 per share. | 04 Mar 2021 | 1,500 | 576,539 (1%) | 0% | 0 | Common Stock | |
| Michael P. Duffy | SVP and General Counsel | Sale of securities on an exchange or to another person at price $ 18.40 per share. | 04 Mar 2021 | 1,737 | 94,948 (0%) | 0% | 18.4 | 31,961 | Common Stock |
| Michael P. Duffy | SVP and General Counsel | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 04 Mar 2021 | 27,056 | 122,004 (0%) | 0% | 0 | Common Stock | |
| Michael P. Duffy | SVP and General Counsel | Sale of securities on an exchange or to another person at price $ 19.16 per share. | 04 Mar 2021 | 5,032 | 116,972 (0%) | 0% | 19.2 | 96,418 | Common Stock |
| John J. Bolla | Chief Operations Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 04 Mar 2021 | 47,348 | 104,693 (0%) | 0% | 0 | Common Stock | |
| John J. Bolla | Chief Operations Officer | Sale of securities on an exchange or to another person at price $ 18.40 per share. | 04 Mar 2021 | 1,887 | 57,345 (0%) | 0% | 18.4 | 34,721 | Common Stock |
| Robert J. Marshall | CFO and Treasurer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 04 Mar 2021 | 59,524 | 136,509 (0%) | 0% | 0 | Common Stock | |
| Robert J. Marshall | CFO and Treasurer | Sale of securities on an exchange or to another person at price $ 18.40 per share. | 04 Mar 2021 | 2,280 | 76,985 (0%) | 0% | 18.4 | 41,952 | Common Stock |
| Istvan Molnar | Chief Medical Officer | Sale of securities on an exchange or to another person at price $ 18.40 per share. | 04 Mar 2021 | 4,027 | 25,130 (0%) | 0% | 18.4 | 74,097 | Common Stock |
| Istvan Molnar | Chief Medical Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 04 Mar 2021 | 33,820 | 58,950 (0%) | 0% | 0 | Common Stock | |
| Paul Blanchfield | Chief Commercial Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 04 Mar 2021 | 33,820 | 60,329 (0%) | 0% | 0 | Common Stock | |
| Paul Blanchfield | Chief Commercial Officer | Sale of securities on an exchange or to another person at price $ 18.40 per share. | 04 Mar 2021 | 4,061 | 26,509 (0%) | 0% | 18.4 | 74,722 | Common Stock |
| Michael P. Duffy | SVP and General Counsel | Sale of securities on an exchange or to another person at price $ 19.08 per share. | 01 Mar 2021 | 1,473 | 101,929 (0%) | 0% | 19.1 | 28,108 | Common Stock |
| John J. Bolla | Chief Operations Officer | Sale of securities on an exchange or to another person at price $ 19.08 per share. | 01 Mar 2021 | 1,187 | 59,232 (0%) | 0% | 19.1 | 22,650 | Common Stock |
| Robert J. Marshall | CFO and Treasurer | Sale of securities on an exchange or to another person at price $ 19.08 per share. | 01 Mar 2021 | 1,465 | 79,265 (0%) | 0% | 19.1 | 27,955 | Common Stock |
| Michael P. Duffy | SVP and General Counsel | Sale of securities on an exchange or to another person at price $ 14.00 per share. | 09 Dec 2020 | 15,000 | 103,402 (0%) | 0% | 14 | 210,000 | Common Stock |
| Robert J. Marshall | CFO and Treasurer | Sale of securities on an exchange or to another person at price $ 13.20 per share. | 16 Oct 2020 | 5,044 | 80,730 (0%) | 0% | 13.2 | 66,571 | Common Stock |
| Michael P. Duffy | SVP and General Counsel | Sale of securities on an exchange or to another person at price $ 14.00 per share. | 06 Oct 2020 | 15,000 | 118,402 (0%) | 0% | 14 | 210,000 | Common Stock |
| Frederick A. Robertson | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 01 Oct 2020 | 1,356 | 50,659 (0%) | 0% | 0 | Common Stock | |
| Brian A. Markison | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 01 Oct 2020 | 2,277 | 39,275 (0%) | 0% | 0 | Common Stock | |
| James H. Thrall | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 01 Oct 2020 | 1,259 | 19,867 (0%) | 0% | 0 | Common Stock | |
| Samuel R. Leno | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 01 Oct 2020 | 1,453 | 45,784 (0%) | 0% | 0 | Common Stock | |
| Julie H. McHugh | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 01 Oct 2020 | 1,259 | 25,857 (0%) | 0% | 0 | Common Stock | |
| Gary J. Pruden | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 01 Oct 2020 | 1,308 | 20,252 (0%) | 0% | 0 | Common Stock | |
| Frederick A. Robertson | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 10 Aug 2020 | 806 | 49,303 (0%) | 0% | 0 | Common Stock | |
| Brian A. Markison | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 10 Aug 2020 | 1,354 | 36,998 (0%) | 0% | 0 | Common Stock | |
| James H. Thrall | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 10 Aug 2020 | 749 | 18,608 (0%) | 0% | 0 | Common Stock | |
| Samuel R. Leno | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 10 Aug 2020 | 864 | 44,331 (0%) | 0% | 0 | Common Stock | |
| Julie H. McHugh | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 10 Aug 2020 | 749 | 24,598 (0%) | 0% | 0 | Common Stock | |
| Gary J. Pruden | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 10 Aug 2020 | 777 | 18,944 (0%) | 0% | 0 | Common Stock | |
| Mary Anne Heino | Director, President & CEO | Sale of securities on an exchange or to another person at price $ 16.02 per share. | 23 Jul 2020 | 3,000 | 604,793 (1%) | 0% | 16.0 | 48,051 | Common Stock |
| Mary Anne Heino | Director, President & CEO | Sale of securities on an exchange or to another person at price $ 16.01 per share. | 15 Jul 2020 | 22,125 | 607,793 (1%) | 0% | 16.0 | 354,254 | Common Stock |
| John J. Bolla | Chief Operations Officer | Sale of securities on an exchange or to another person at price $ 14.29 per share. | 16 Jun 2020 | 2,422 | 60,419 (0%) | 0% | 14.3 | 34,603 | Common Stock |
| Michael P. Duffy | SVP and General Counsel | Sale of securities on an exchange or to another person at price $ 13.13 per share. | 28 Apr 2020 | 7,198 | 133,402 (0%) | 0% | 13.1 | 94,529 | Common Stock |
| Mary Anne Heino | Director, President & CEO | Sale of securities on an exchange or to another person at price $ 13.77 per share. | 27 Apr 2020 | 30,033 | 634,318 (1%) | 0% | 13.8 | 413,407 | Common Stock |
| Michael P. Duffy | SVP and General Counsel | Sale of securities on an exchange or to another person at price $ 14.58 per share. | 06 Mar 2020 | 1,936 | 140,600 (0%) | 0% | 14.6 | 28,229 | Common Stock |
| Frederick A. Robertson | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 03 Mar 2020 | 8,095 | 48,497 (0%) | 0% | 0 | Common Stock | |
| Brian A. Markison | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 03 Mar 2020 | 8,095 | 35,644 (0%) | 0% | 0 | Common Stock | |
| Derace L. Schaffer | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 03 Mar 2020 | 8,095 | 25,089 (0%) | 0% | 0 | Common Stock | |
| James H. Thrall | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 03 Mar 2020 | 8,095 | 17,859 (0%) | 0% | 0 | Common Stock | |
| Kenneth J. Pucel | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 03 Mar 2020 | 8,095 | 21,359 (0%) | 0% | 0 | Common Stock | |
| Samuel R. Leno | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 03 Mar 2020 | 8,095 | 43,467 (0%) | 0% | 0 | Common Stock | |
| Mary Anne Heino | Director, President & CEO | Sale of securities on an exchange or to another person at price $ 15.35 per share. | 03 Mar 2020 | 9,019 | 664,351 (1%) | 0% | 15.3 | 138,408 | Common Stock |
| Mary Anne Heino | Director, President & CEO | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 03 Mar 2020 | 148,971 | 673,370 (1%) | 0% | 0 | Common Stock | |
| James C. Clemmer | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 03 Mar 2020 | 8,095 | 62,082 (0%) | 0% | 0 | Common Stock | |
| Julie H. McHugh | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 03 Mar 2020 | 8,095 | 23,849 (0%) | 0% | 0 | Common Stock | |
| Michael P. Duffy | SVP and General Counsel | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 03 Mar 2020 | 26,043 | 142,536 (0%) | 0% | 0 | Common Stock | |
| Gary J. Pruden | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 03 Mar 2020 | 8,095 | 18,167 (0%) | 0% | 0 | Common Stock | |
| John J. Bolla | Chief Operations Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 03 Mar 2020 | 27,687 | 62,841 (0%) | 0% | 0 | Common Stock | |
| Robert J. Marshall | CFO and Treasurer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 03 Mar 2020 | 34,781 | 85,774 (0%) | 0% | 0 | Common Stock | |
| Istvan Molnar | Chief Medical Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 03 Mar 2020 | 29,000 | 29,000 (0%) | 0% | 0 | Common Stock | |
| Paul Blanchfield | Chief Commercial Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 03 Mar 2020 | 29,000 | 29,000 (0%) | 0% | 0 | Common Stock | |
| Frederick A. Robertson | Director | Sale of securities on an exchange or to another person at price $ 15.86 per share. | 27 Feb 2020 | 2,660 | 40,402 (0%) | 0% | 15.9 | 42,193 | Common Stock |
| Samuel R. Leno | Director | Sale of securities on an exchange or to another person at price $ 15.85 per share. | 27 Feb 2020 | 2,700 | 35,372 (0%) | 0% | 15.8 | 42,792 | Common Stock |
| Julie H. McHugh | Director | Sale of securities on an exchange or to another person at price $ 15.86 per share. | 27 Feb 2020 | 1,756 | 15,754 (0%) | 0% | 15.9 | 27,845 | Common Stock |
| Michael P. Duffy | SVP and General Counsel | Sale of securities on an exchange or to another person at price $ 15.79 per share. | 27 Feb 2020 | 1,552 | 116,493 (0%) | 0% | 15.8 | 24,501 | Common Stock |
| John J. Bolla | Chief Operations Officer | Sale of securities on an exchange or to another person at price $ 15.79 per share. | 27 Feb 2020 | 1,251 | 35,154 (0%) | 0% | 15.8 | 19,750 | Common Stock |
| Robert J. Marshall | CFO and Treasurer | Sale of securities on an exchange or to another person at price $ 15.45 per share. | 27 Feb 2020 | 889 | 50,993 (0%) | 0% | 15.4 | 13,731 | Common Stock |
| Robert J. Marshall | CFO and Treasurer | Sale of securities on an exchange or to another person at price $ 15.79 per share. | 27 Feb 2020 | 1,546 | 51,882 (0%) | 0% | 15.8 | 24,407 | Common Stock |
| Mary Anne Heino | Director, President & CEO | Sale of securities on an exchange or to another person at price $ 16.05 per share. | 26 Feb 2020 | 25,000 | 524,399 (1%) | 0% | 16.1 | 401,288 | Common Stock |
| Mary Anne Heino | Director, President & CEO | Sale of securities on an exchange or to another person at price $ 17.09 per share. | 26 Feb 2020 | 6,615 | 549,399 (1%) | 0% | 17.1 | 113,031 | Common Stock |
| Michael P. Duffy | SVP and General Counsel | Sale of securities on an exchange or to another person at price $ 16.85 per share. | 25 Feb 2020 | 6,563 | 118,045 (0%) | 0% | 16.8 | 110,567 | Common Stock |
| Mary Anne Heino | Director, President & CEO | Sale of securities on an exchange or to another person at price $ 16.06 per share. | 24 Feb 2020 | 9,898 | 556,014 (1%) | 0% | 16.1 | 158,970 | Common Stock |
| Mary Anne Heino | Director, President & CEO | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 19 Feb 2020 | 2,878 | 565,912 (1%) | 0% | 0 | Common Stock | |
| Michael P. Duffy | SVP and General Counsel | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 19 Feb 2020 | 718 | 124,608 (0%) | 0% | 0 | Common Stock | |
| Mary Anne Heino | Director, President & CEO | Sale of securities on an exchange or to another person at price $ 20.85 per share. | 20 Dec 2019 | 19,260 | 563,034 (1%) | 0% | 20.9 | 401,602 | Common Stock |
| Robert J. Marshall | CFO and Treasurer | Sale of securities on an exchange or to another person at price $ 20.82 per share. | 16 Dec 2019 | 6,351 | 53,428 (0%) | 0% | 20.8 | 132,228 | Common Stock |
| Samuel R. Leno | None | Sale of securities on an exchange or to another person at price $ 20.30 per share. | 13 Dec 2019 | 11,508 | 38,072 (0%) | 0% | 20.3 | 233,555 | Common Stock |
| Michael P. Duffy | SVP and General Counsel | Sale of securities on an exchange or to another person at price $ 20.79 per share. | 14 Nov 2019 | 7,500 | 123,890 (0%) | 0% | 20.8 | 155,925 | Common Stock |
| Robert J. Marshall | CFO and Treasurer | Sale of securities on an exchange or to another person at price $ 19.07 per share. | 16 Oct 2019 | 4,809 | 59,779 (0%) | 0% | 19.1 | 91,698 | Common Stock |
| Mary Anne Heino | Director, President & CEO | Sale of securities on an exchange or to another person at price $ 25.81 per share. | 20 Sep 2019 | 15,590 | 582,294 (1%) | 0% | 25.8 | 402,448 | Common Stock |
| Michael P. Duffy | SVP and General Counsel | Sale of securities on an exchange or to another person at price $ 23.74 per share. | 12 Sep 2019 | 7,500 | 131,390 (0%) | 0% | 23.7 | 178,028 | Common Stock |
| Michael P. Duffy | SVP and General Counsel | Sale of securities on an exchange or to another person at price $ 20.60 per share. | 04 Sep 2019 | 5,604 | 138,890 (0%) | 0% | 20.6 | 115,465 | Common Stock |
| Mary Anne Heino | Director, President & CEO | Sale of securities on an exchange or to another person at price $ 21.21 per share. | 03 Sep 2019 | 25,538 | 597,884 (1%) | 0% | 21.2 | 541,679 | Common Stock |
| Brian A. Markison | None | Sale of securities on an exchange or to another person at price $ 28.07 per share. | 10 Jul 2019 | 4,918 | 27,549 (0%) | 0% | 28.1 | 138,048 | Common Stock |
| Michael P. Duffy | SVP and General Counsel | Sale of securities on an exchange or to another person at price $ 28.14 per share. | 10 Jul 2019 | 8,819 | 144,494 (0%) | 0% | 28.1 | 248,167 | Common Stock |
| Cesare Orlandi | Chief Medical Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 21.10 per share. | 08 Jul 2019 | 8,896 | 104,069 (0%) | 0% | 21.1 | 187,706 | Common Stock |
| Cesare Orlandi | Chief Medical Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 08 Jul 2019 | 8,896 | 0 | - | - | Stock Option (right to buy) | |
| Cesare Orlandi | Chief Medical Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 08 Jul 2019 | 6,672 | 0 | - | - | Stock Option (right to buy) | |
| Cesare Orlandi | Chief Medical Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 08 Jul 2019 | 13,346 | 0 | - | - | Stock Option (right to buy) | |
| Cesare Orlandi | Chief Medical Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 08 Jul 2019 | 6,672 | 0 | - | - | Stock Option (right to buy) | |
| Cesare Orlandi | Chief Medical Officer | Sale of securities on an exchange or to another person at price $ 27.60 per share. | 08 Jul 2019 | 7,584 | 68,483 (0%) | 0% | 27.6 | 209,318 | Common Stock |
| Cesare Orlandi | Chief Medical Officer | Sale of securities on an exchange or to another person at price $ 28.33 per share. | 08 Jul 2019 | 28,002 | 76,067 (0%) | 0% | 28.3 | 793,297 | Common Stock |
| Cesare Orlandi | Chief Medical Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 21.10 per share. | 08 Jul 2019 | 6,672 | 95,173 (0%) | 0% | 21.1 | 140,779 | Common Stock |
| Cesare Orlandi | Chief Medical Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 21.10 per share. | 08 Jul 2019 | 13,346 | 88,501 (0%) | 0% | 21.1 | 281,601 | Common Stock |
| Cesare Orlandi | Chief Medical Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 21.10 per share. | 08 Jul 2019 | 6,672 | 75,155 (0%) | 0% | 21.1 | 140,779 | Common Stock |
| Brian A. Markison | None | Sale of securities on an exchange or to another person at price $ 28.41 per share. | 03 Jul 2019 | 5,000 | 32,467 (0%) | 0% | 28.4 | 142,050 | Common Stock |
| Brian A. Markison | None | Sale of securities on an exchange or to another person at price $ 27.67 per share. | 26 Jun 2019 | 5,000 | 37,467 (0%) | 0% | 27.7 | 138,361 | Common Stock |
| Mary Anne Heino | Director, President & CEO | Sale of securities on an exchange or to another person at price $ 28.48 per share. | 20 Jun 2019 | 1,575 | 623,422 (1%) | 0% | 28.5 | 44,856 | Common Stock |
| Mary Anne Heino | Director, President & CEO | Sale of securities on an exchange or to another person at price $ 27.82 per share. | 20 Jun 2019 | 12,765 | 624,997 (1%) | 0% | 27.8 | 355,079 | Common Stock |
| Brian A. Markison | None | Sale of securities on an exchange or to another person at price $ 27.40 per share. | 19 Jun 2019 | 5,000 | 42,467 (0%) | 0% | 27.4 | 137,015 | Common Stock |
| John J. Bolla | Chief Operations Officer | Sale of securities on an exchange or to another person at price $ 27.58 per share. | 18 Jun 2019 | 2,241 | 36,405 (0%) | 0% | 27.6 | 61,807 | Common Stock |
| Brian A. Markison | None | Sale of securities on an exchange or to another person at price $ 25.27 per share. | 12 Jun 2019 | 5,000 | 47,467 (0%) | 0% | 25.3 | 126,365 | Common Stock |
| Samuel R. Leno | None | Sale of securities on an exchange or to another person at price $ 25.33 per share. | 07 Jun 2019 | 3,950 | 49,580 (0%) | 0% | 25.3 | 100,059 | Common Stock |
| Derace L. Schaffer | None | Sale of securities on an exchange or to another person at price $ 24.11 per share. | 03 Jun 2019 | 8,920 | 28,074 (0%) | 0% | 24.1 | 215,081 | Common Stock |
| Derace L. Schaffer | None | Sale of securities on an exchange or to another person at price $ 24.61 per share. | 03 Jun 2019 | 1,080 | 26,994 (0%) | 0% | 24.6 | 26,578 | Common Stock |
| Derace L. Schaffer | None | Sale of securities on an exchange or to another person at price $ 23.47 per share. | 03 Jun 2019 | 10,000 | 36,994 (0%) | 0% | 23.5 | 234,725 | Common Stock |
| Brian A. Markison | None | Sale of securities on an exchange or to another person at price $ 24.29 per share. | 29 May 2019 | 5,000 | 57,467 (0%) | 0% | 24.3 | 121,454 | Common Stock |
| Brian A. Markison | None | Sale of securities on an exchange or to another person at price $ 24.73 per share. | 22 May 2019 | 5,000 | 62,467 (0%) | 0% | 24.7 | 123,628 | Common Stock |
| Mary Anne Heino | Director, President & CEO | Sale of securities on an exchange or to another person at price $ 23.89 per share. | 20 May 2019 | 16,827 | 637,762 (1%) | 0% | 23.9 | 401,940 | Common Stock |
| Brian A. Markison | None | Sale of securities on an exchange or to another person at price $ 24.75 per share. | 15 May 2019 | 5,000 | 67,467 (0%) | 0% | 24.8 | 123,755 | Common Stock |
| Brian A. Markison | None | Sale of securities on an exchange or to another person at price $ 25.22 per share. | 08 May 2019 | 5,000 | 72,467 (0%) | 0% | 25.2 | 126,116 | Common Stock |
| Brian A. Markison | None | Sale of securities on an exchange or to another person at price $ 23.91 per share. | 30 Apr 2019 | 5,000 | 77,467 (0%) | 0% | 23.9 | 119,537 | Common Stock |
| Brian A. Markison | None | Sale of securities on an exchange or to another person at price $ 24.30 per share. | 30 Apr 2019 | 5,000 | 82,467 (0%) | 0% | 24.3 | 121,519 | Common Stock |
| Michael P. Duffy | See Remarks | Sale of securities on an exchange or to another person at price $ 24.84 per share. | 29 Apr 2019 | 6,908 | 153,313 (0%) | 0% | 24.8 | 171,615 | Common Stock |
| Cesare Orlandi | Chief Medical Officer | Sale of securities on an exchange or to another person at price $ 24.85 per share. | 29 Apr 2019 | 11,250 | 68,483 (0%) | 0% | 24.9 | 279,617 | Common Stock |
| Mary Anne Heino | Director, President & CEO | Sale of securities on an exchange or to another person at price $ 24.86 per share. | 26 Apr 2019 | 29,813 | 654,589 (1%) | 0% | 24.9 | 741,074 | Common Stock |
| Brian A. Markison | None | Sale of securities on an exchange or to another person at price $ 24.07 per share. | 23 Apr 2019 | 5,000 | 87,467 (0%) | 0% | 24.1 | 120,368 | Common Stock |
| Brian A. Markison | None | Sale of securities on an exchange or to another person at price $ 25.26 per share. | 16 Apr 2019 | 5,000 | 92,467 (0%) | 0% | 25.3 | 126,298 | Common Stock |
| Mary Anne Heino | Director, President & CEO | Sale of securities on an exchange or to another person at price $ 25.40 per share. | 12 Apr 2019 | 15,799 | 684,402 (1%) | 0% | 25.4 | 401,317 | Common Stock |
| Derace L. Schaffer | None | Sale of securities on an exchange or to another person at price $ 24.41 per share. | 01 Apr 2019 | 10,000 | 46,994 (0%) | 0% | 24.4 | 244,094 | Common Stock |
| Frederick A. Robertson | None | Sale of securities on an exchange or to another person at price $ 22.77 per share. | 06 Mar 2019 | 3,932 | 43,062 (0%) | 0% | 22.8 | 89,536 | Common Stock |
| James H. Thrall | None | Sale of securities on an exchange or to another person at price $ 22.78 per share. | 06 Mar 2019 | 3,500 | 9,764 (0%) | 0% | 22.8 | 79,723 | Common Stock |
| Julie H. McHugh | None | Sale of securities on an exchange or to another person at price $ 22.76 per share. | 06 Mar 2019 | 2,595 | 17,510 (0%) | 0% | 22.8 | 59,075 | Common Stock |
| Michael P. Duffy | See Remarks | Sale of securities on an exchange or to another person at price $ 22.77 per share. | 06 Mar 2019 | 1,789 | 160,221 (0%) | 0% | 22.8 | 40,734 | Common Stock |
| Cesare Orlandi | Chief Medical Officer | Sale of securities on an exchange or to another person at price $ 22.77 per share. | 06 Mar 2019 | 4,271 | 79,733 (0%) | 0% | 22.8 | 97,238 | Common Stock |
| Gary J. Pruden | None | Sale of securities on an exchange or to another person at price $ 22.77 per share. | 06 Mar 2019 | 3,192 | 10,072 (0%) | 0% | 22.8 | 72,672 | Common Stock |
| Mary Anne Heino | Director, President & CEO | Sale of securities on an exchange or to another person at price $ 23.34 per share. | 04 Mar 2019 | 9,019 | 700,201 (1%) | 0% | 23.3 | 210,483 | Common Stock |
| Mary Anne Heino | Director, President & CEO | Sale of securities on an exchange or to another person at price $ 23.68 per share. | 04 Mar 2019 | 275 | 709,220 (1%) | 0% | 23.7 | 6,512 | Common Stock |
| Frederick A. Robertson | None | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 26 Feb 2019 | 5,353 | 46,994 (0%) | 0% | 0 | Common Stock | |
| Brian A. Markison | None | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 26 Feb 2019 | 5,353 | 97,467 (0%) | 0% | 0 | Common Stock | |
| Derace L. Schaffer | None | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 26 Feb 2019 | 5,353 | 56,994 (0%) | 0% | 0 | Common Stock | |
| James H. Thrall | None | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 26 Feb 2019 | 5,353 | 13,264 (0%) | 0% | 0 | Common Stock | |
| Kenneth J. Pucel | None | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 26 Feb 2019 | 5,353 | 13,264 (0%) | 0% | 0 | Common Stock | |
| Samuel R. Leno | None | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 26 Feb 2019 | 5,353 | 53,530 (0%) | 0% | 0 | Common Stock | |
| James C. Clemmer | None | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 26 Feb 2019 | 5,353 | 53,987 (0%) | 0% | 0 | Common Stock | |
| Julie H. McHugh | None | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 26 Feb 2019 | 5,353 | 20,105 (0%) | 0% | 0 | Common Stock | |
| Michael P. Duffy | See Remarks | Sale of securities on an exchange or to another person at price $ 23.17 per share. | 26 Feb 2019 | 2,360 | 162,010 (0%) | 0% | 23.2 | 54,681 | Common Stock |
| Michael P. Duffy | See Remarks | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 26 Feb 2019 | 20,044 | 164,370 (0%) | 0% | 0 | Common Stock | |
| Cesare Orlandi | Chief Medical Officer | Sale of securities on an exchange or to another person at price $ 23.10 per share. | 26 Feb 2019 | 3,111 | 84,004 (0%) | 0% | 23.1 | 71,870 | Common Stock |
| Cesare Orlandi | Chief Medical Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 26 Feb 2019 | 13,426 | 87,115 (0%) | 0% | 0 | Common Stock | |
| Gary J. Pruden | None | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 26 Feb 2019 | 5,353 | 13,264 (0%) | 0% | 0 | Common Stock | |
| John J. Bolla | See Remarks | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 26 Feb 2019 | 16,154 | 38,774 (0%) | 0% | 0 | Common Stock | |
| Robert J. Marshall | CFO and Treasurer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 26 Feb 2019 | 19,946 | 64,588 (0%) | 0% | 0 | Common Stock | |
| Mary Anne Heino | Director, President & CEO | Sale of securities on an exchange or to another person at price $ 24.06 per share. | 25 Feb 2019 | 9,456 | 621,326 (1%) | 0% | 24.1 | 227,519 | Common Stock |